Ligand-Enabled Alkynylation of C(sp³)−H Bonds with Palladium(II) Catalysts

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• 作者：Dr. Haiyan Fu ; Peng-Xiang Shen ; Jian He ; Dr. Fanglin Zhang ; Dr. Suhua Li ; Dr. Peng Wang ; Tao Liu and Prof. Dr. Jin-Quan Yu
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：February 6, 2017
• 年：2017
• 卷：56
• 期：7
• 页码：1873-1876
• 全文大小：697K
• ISSN：1521-3773

文摘

The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp³)−H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp³)−H bonds of various carbocyclic rings were also successfully alkynylated.