SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals

详细信息    查看全文

• 作者：H. Li ; C. L. Lv ; C. S. Yang ; D. F. Wei ; K. W. Chen ; S. W. Li and Z. J. Zhang
• 刊名：European Journal of Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：187-194
• 全文大小：537K
• ISSN：1468-1331

文摘

SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population.