Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats

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• 作者：Ulrich Frischknecht ; Derik Hermann ; Nuran Tunc-Skarka ; Guo-Ying Wang ; Markus Sack ; Julia van Eijk ; Traute Demirakca ; Claudia Falfan-Melgoza ; Bertram Krumm ; Sandra Dieter ; Rainer Spanagel ; Falk Kiefer ; Karl F. Mann ; Wolfgang H. Sommer ; Gabriele Ende and Wolfgang Weber-Fahr
• 刊名：Alcoholism: Clinical and Experimental Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：41
• 期：2
• 页码：323-333
• 全文大小：456K
• ISSN：1530-0277

文摘

Both chronic alcohol consumption and alcohol withdrawal lead to neural tissue damage which partly recovers during abstinence. This study investigated withdrawal-associated changes in glutamatergic compounds, markers of neuronal integrity, and gray matter volumes during acute alcohol withdrawal in the hippocampus, a key region in development and maintenance of alcohol dependence in humans and rats.