Maximum levels of hepatitis C virus lipoviral particles are associated with early and persistent infection

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• 作者：David A. Sheridan ; Behzad Hajarizadeh ; Fiona I. Fenwick ; Gail V. Matthews ; Tanya Applegate ; Mark Douglas ; Dermot Neely ; Bev Askew ; Gregory J. Dore ; Andrew R. Lloyd ; Jacob George ; Margaret F. Bassendine and Jason Grebely
• 刊名：Liver International
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：36
• 期：12
• 页码：1774-1782
• 全文大小：367K
• ISSN：1478-3231

文摘

Hepatitis C virus (HCV) is bound to plasma lipoproteins and circulates as an infectious lipoviral particle (LVP). Experimental evidence indicates that LVPs have decreased susceptibility to antibody-mediated neutralisation and higher infectivity. This study tested the hypothesis that LVPs are required to establish persistent infection, and conversely, low levels of LVP in recent HCV infection increase the probability of spontaneous HCV clearance.