Poor immune reconstitution is associated with symptomatic BK polyomavirus viruria in allogeneic stem cell transplant recipients

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• 作者：Ala Abudayyeh ; Amir Hamdi ; Maen Abdelrahim ; Heather Lin ; Valda D. Page ; Gabriela Rondon ; Borje S. Andersson ; Aimaz Afrough ; Charles S. Martinez ; Jeffrey J. Tarrand ; Dimitrios P. Kontoyiannis ; David Marin ; A. Osama Gaber ; Betul Oran ; Roy F. Chemaly ; Sairah Ahmed ; Islam Abudayyeh ; Amanda Olson ; Roy Jones ; Uday Popat ; Richard E. Champlin ; Elizabeth J. Shpall and Katayoun Rezvani
• 刊名：Transplant Infectious Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：809K
• ISSN：1399-3062

文摘

BK polyomavirus (BKPyV) infections are known indicators of immune suppression in hematopoietic stem cell transplant (HSCT) recipients; they can lead to hemorrhagic cystitis, ureteral stenosis, renal dysfunction, and prolonged hospital stays. In this study, we determined transplant-associated variables and immune parameters that can predict for the risk of BKPyV viruria. We hypothesized that BKPyV infection is a marker of poor immune recovery.