Enhanced Th2 cell differentiation and function in the absence of Nox2

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• 作者：B.-I. Kwon ; T. W. Kim ; K. Shin ; Y. H. Kim ; C. M. Yuk ; J.-M. Yuk ; D.-M. Shin ; E.-K. Jo ; C.-H. Lee and S.-H. Lee
• 刊名：Allergy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：72
• 期：2
• 页码：252-265
• 全文大小：1680K
• ISSN：1398-9995

文摘

Patients with chronic granulomatous disease (CGD), whom inherit abnormal function of NADPH oxidase 2 (Nox2), suffer from hyperinflammatory responses in lung as well as bacterial and fungal infection. There have been studies to reveal the function of Nox2 in hyperinflammatory diseases, especially in asthma, but the exact role of Nox2 in asthma is still unclear and controversial. Therefore, we attempted to clarify the exact role of Nox2 in asthma, using various experimental asthma models.