Baboon envelope pseudotyped lentiviral vectors efficiently transduce human B cells and allow active factor IX B cell secretion in vivo in NOD/SCIDγc^-/- mice

详细信息    查看全文

• 作者：C. Levy ; F. Fusil ; F. Amirache ; C. Costa ; A. Girard-Gagnepain ; D. Negre ; O. Bernadin ; G. Garaulet ; A. Rodriguez ; N. Nair ; T. Vandendriessche ; M. Chuah ; F-L. Cosset and E. Verhoeyen
• 刊名：Journal of Thrombosis and Haemostasis
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：12
• 页码：2478-2492
• 全文大小：934K
• ISSN：1538-7836

文摘

B cells are attractive targets for gene therapy for diseases associated with B-cell dysfunction and particularly interesting for immunotherapy. Moreover, B cells are potent protein-secreting cells and can be tolerogenic antigen-presenting cells.