Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP

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• 作者：Yunyan Wei ; Shuangshuang Wu ; Wei Xu ; Yan Liang ; Yue Li ; Weihong Zhao and Jianqing Wu
• 刊名：Thoracic Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：26-32
• 全文大小：444K
• ISSN：1759-7714

文摘

Cisplatin is the standard first-line chemotherapeutic agent for the treatment of non-small cell lung cancer (NSCLC). However, resistance to chemotherapy has been a major obstacle in the management of NSCLC. Aldehyde dehydrogenase 1A1 (ALDH1A1) overexpression has been observed in a variety of cancers, including lung cancer. The purpose of this study was to investigate the effect of ALDH1A1 expression on cisplatin resistance and explore the mechanism responsible.