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D
esign an
d
Synt
h
esis of Novel 6-(5-Met
h
yl-1
H
-1,2,3-triazol-4-yl)-5-[(2-(t
h
iazol-2-yl)
h
y
d
razono)met
h
yl]imi
d
azo[2,1-
b
]t
h
iazoles as Antimicrobial Agents
详细信息
查看全文
作者:
Bakr F. Ab
d
el-Wa
h
ab
;
Rizk E. K
h
i
d
re an
d
G
h
a
d
a E. A. Awa
d
刊名:Journal of
H
eterocyc
li
c C
h
emistry
出版年:2017
出版时间:January 2017
年:2017
卷:54
期:1
页码:489-494
全文大小:425K
ISSN:1943-5193
文摘
Novel 6-(1,2,3-triazol-4-yl)-5-[(2-(t
h
iazol-2-yl)
h
y
d
razono)met
h
yl]imi
d
azo[2,1-
b
]t
h
iazoles
href="#j
h
et2610-eo-0015" rel="references:#j
h
et2610-eo-0015">
,
href="#j
h
et2610-eo-0022" rel="references:#j
h
et2610-eo-0022 #j
h
et2610-eo-0023 #j
h
et2610-eo-0024 #j
h
et2610-eo-0025">
, an
d
href="#j
h
et2610-eo-0027" rel="references:#j
h
et2610-eo-0027">
were prepare
d
by reaction of t
h
iosemicarbazone
href="#j
h
et2610-eo-0012" rel="references:#j
h
et2610-eo-0012 #j
h
et2610-eo-0013">
wit
h
eit
h
er
h
y
d
razonoyl c
h
lori
d
e
href="#j
h
et2610-eo-0014" rel="references:#j
h
et2610-eo-0014">
, p
h
enacylbromi
d
es
href="#j
h
et2610-eo-0016" rel="references:#j
h
et2610-eo-0016">
or
http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-on
li
ne-
li
brary/content/ren
d
er" xmlns:mml="
h
ttp://www.w3.org/1998/Mat
h
/Mat
h
ML" i
d
="j
h
et2610-eo-0004">
http://www.wiley.com/namespaces/wiley" xmlns:cr="urn://wiley-on
li
ne-
li
brary/content/ren
d
er" xmlns:mml="
h
ttp://www.w3.org/1998/Mat
h
/Mat
h
ML" i
d
="j
h
et2610-eo-0026">
2-bromo-1-(5-met
h
yl-1-
p
-tolyl-1
H
-1,2,3-triazol-4-yl)et
h
anone
href="#j
h
et2610-eo-0026" rel="references:#j
h
et2610-eo-0026">
respectively. T
h
e new pro
d
ucts were teste
d
for t
h
eir antimicrobial activities using 96-well micro-plate assay, an
d
compoun
d
href="#j
h
et2610-eo-0015" rel="references:#j
h
et2610-eo-0015">
s
h
owe
d
excellent antibacterial activities compare
d
wit
h
Vancomycine (reference
d
rugs), w
h
ile compoun
d
s
href="#j
h
et2610-eo-0013" rel="references:#j
h
et2610-eo-0013">
an
d
href="#j
h
et2610-eo-0024" rel="references:#j
h
et2610-eo-0024">
ex
h
ibite
d
goo
d
results against yeast. T
h
e minimum in
h
ibitory concentration (MIC) was
d
etermine
d
, an
d
compoun
d
href="#j
h
et2610-eo-0015" rel="references:#j
h
et2610-eo-0015">
s
h
owe
d
t
h
e lowest MIC against Gram positive bacteria w
h
ile compoun
d
href="#j
h
et2610-eo-0013" rel="references:#j
h
et2610-eo-0013">
s
h
owe
d
t
h
e lowest MIC against yeast.
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