Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

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• 作者：Yu Liu ; Ning Kang ; Jing Lv ; Zijian Zhou ; Qingliang Zhao ; Lingceng Ma ; Zhong Chen ; Lei Ren and Liming Nie
• 刊名：Advanced Materials
• 出版年：2016
• 出版时间：August 10, 2016
• 年：2016
• 卷：28
• 期：30
• 页码：6411-6419
• 全文大小：6140K
• ISSN：1521-4095

文摘

A gadolinium-doped multi-shell upconversion nanoparticle under 800 nm excitation is synthesized with a 10-fold fluorescence-intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri-modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at a new imaging depth.