MYC amplification in angiosarcomas arising in the setting of chronic lymphedema of morbid obesity

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• 作者：David Harker ; Michael Jennings ; Patrick McDonough ; Melissa Mauskar ; Stephanie Savory ; Gregory A. Hosler and Travis Vandergriff
• 刊名：Journal of Cutaneous Pathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：44
• 期：1
• 页码：15-19
• 全文大小：1274K
• ISSN：1600-0560

文摘

Angiosarcoma is a malignancy of vascular endothelial cells which may arise secondarily as a complication of lymphedema, including chronic lymphedema of morbid obesity. Amplifications in MYC are frequently present in secondary angiosarcoma (arising in irradiated sites and chronic lymphedema) and less frequently in primary cutaneous angiosarcoma.