Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

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• 作者：Elena Ló ; pez-Isac ; Jose-Ezequiel Martí ; n ; Shervin Assassi ; Carmen P. Simeó ; n ; Patricia Carreira ; Norberto Ortego-Centeno ; Mayka Freire ; Emma Beltrá ; n ; Javier Narvá ; ez ; Juan J. Alegre-Sancho ; the Spanish Scleroderma Group ; Benjamí ; n Ferná ; ndez-Gutié ; rrez ; Alejandro Balsa ; Ana M. Ortiz ; Miguel A. Gonzá ; lez-Gay ; Lorenzo Beretta ; Alessandro Santaniello ; Chiara Bellocchi ; Claudio Lunardi ; Gianluca Moroncini ; Armando Gabrielli ; Torsten Witte ; Nicolas Hunzelmann ; Jö ; rg H. W. Distler ; Gabriella Riekemasten ; Annette H. van der Helm-van Mil ; Jeska de Vries-Bouwstra ; Cesar Magro-Checa ; Alexandre E. Voskuyl ; Madelon C. Vonk ; Ø ; yvind Molberg ; Tony Merriman ; Roger Hesselstrand ; Annika Nordin ; Leonid Padyukov ; Ariane Herrick ; Steve Eyre ; Bobby P. C. Koeleman ; Christopher P. Denton ; Carmen Fonseca ; Timothy R. D. J. Radstake ; Jane Worthington ; Maureen D. Mayes and Javier Martí ; n
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：68
• 期：9
• 页码：2338-2344
• 全文大小：165K
• ISSN：1529-0131

文摘

Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy.