Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

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• 作者：Yuichi Maeda ; Takashi Kurakawa ; Eiji Umemoto ; Daisuke Motooka ; Yoshinaga Ito ; Kazuyoshi Gotoh ; Keiji Hirota ; Masato Matsushita ; Yoki Furuta ; Masashi Narazaki ; Noriko Sakaguchi ; Hisako Kayama ; Shota Nakamura ; Tetsuya Iida ; Yukihiko Saeki ; Atsushi Kumanogoh ; Shimon Sakaguchi and Kiyoshi Takeda
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：68
• 期：11
• 页码：2646-2661
• 全文大小：897K
• ISSN：1529-0131

文摘

The intestinal microbiota is involved in the pathogenesis of arthritis. Altered microbiota composition has been demonstrated in patients with rheumatoid arthritis (RA). However, it remains unclear how dysbiosis contributes to the development of arthritis. The aim of this study was to investigate whether altered composition of human intestinal microbiota in RA patients contributes to the development of arthritis.