Claudin-2-mediated cation and water transport share a common pore

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• 作者：R. Rosenthal ; D. Gü ; nzel ; S. M. Krug ; J.-D. Schulzke ; M. Fromm and A. S. L. Yu
• 刊名：Acta Physiologica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：219
• 期：2
• 页码：521-536
• 全文大小：1545K
• ISSN：1748-1716

文摘

Claudin-2 is a tight junction protein typically located in ‘leaky’ epithelia exhibiting large paracellular permeabilities like small intestine and proximal kidney tubule. Former studies revealed that claudin-2 forms paracellular channels for small cations like sodium and potassium and also paracellular channels for water. This study analyses whether the diffusive transport of sodium and water occurs through a common pore of the claudin-2 channel.