Asymmetric Catalytic Aza-Diels-Alder/Ring-Closing Cascade Reaction Forming Bicyclic Azaheterocycles by Trienamine Catalysis

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• 作者：Yang Li ; Casper Barl&oslash ; se ; Julie J&oslash ; rgensen ; Bj&oslash ; rn Drei&oslash ; Carlsen and Prof. Dr. Karl Anker J&oslash ; rgensen
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 1, 2017
• 年：2017
• 卷：23
• 期：1
• 页码：3
• 全文大小：562K
• ISSN：1521-3765

文摘

Invited for the cover of this issue is the group of Karl Anker Jørgensen at Aarhus University. The image depicts the basic reaction concept of the asymmetric catalytic aza-Diels–Alder/ring-closing cascade by the operation mode of a zipper. The two molecules (red 2,4-dienal; blue hydrazone) in this reaction are mosaicked into the two chains of the zipper. The chiral slider, the diarylprolinol-silyl ether catalyst, zips together the two molecules by sliding the hand down the chains forming the bicyclic aza-heterocyclic products in a highly stereoselective manner. Read the full text of the article at 10.1002/chem.201604310.