The synthesis of [1-¹⁴C]2-(1H-tetrazol-5-yl)acetic acid

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• 作者：Brad D. Maxwell and Scott B. Tran
• 刊名：Journal of Labelled Compounds and Radiopharmaceuticals
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：1
• 页码：49-54
• 全文大小：892K
• ISSN：1099-1344

文摘

Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1-¹⁴C]2-(1H-Tetrazol-5-yl)acetic acid was required as an intermediate in the synthesis of a development candidate as part of a discovery phase program to complete metabolic profiling studies. [1-¹⁴C]2-(1H-Tetrazol-5-yl)acetic acid was prepared in 4 steps overall and in 3 radiochemical steps from K¹⁴CN in an overall 32% radiochemical yield.