Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines

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• 作者：Wen-Juan Hao ; Peng Zhou ; Fei-Yue Wu ; Bo Jiang ; Shu-Jiang Tu and Guigen Li
• 关键词：Multicomponent reactions ; Microwave chemistry ; Cyclization ; Polycycles ; Fused-ring systems
• 刊名：European Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：2016
• 期：11
• 页码：1968-1971
• 全文大小：707K
• ISSN：1099-0690

文摘

A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, -thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C–N and C–C bonds, to give high levels of molecular complexity.