Catalyst-free Synthesis of 5-Arylimidazo[1,2-c]quinazoline Derivatives in Ionic Liquids

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• 作者：Wen-Wen Qiang ; Mei-Mei Zhang and Xiang-Shan Wang
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：509-516
• 全文大小：688K
• ISSN：1943-5193

文摘

The reaction of 2-(4,5-diphenyl-1H-imidazol-2-yl)aniline and aromatic aldehyde was treated in ionic liquids under catalyst-free condition and gave dehydrogenated 5-aryl-2,3-diphenylimidazo[1,2-c]quinazolines. The same reaction gave un-aromatized 5-aryl-2,3-diphenyl-5,6-dihydroimidazo[1,2-c]quinazoline derivatives while it was controlled in an inert gas. This procedure approach to imidazo[1,2-c]quinazolines has the advantages of milder reaction conditions, one-pot, catalyst free, high yields, and environmentally benign.