Triphenylphosphine (PPh₃) Catalyzed Erlenmeyer Reaction for Azlactones under Solvent-free Conditions

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• 作者：Alapati Mohan Lakshmi Punna Rao ; Abburi Sridhar Rao ; Mukkamala Saratchandra Babu and M. Krishnaji Rao
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：429-435
• 全文大小：1969K
• ISSN：1943-5193

文摘

This study presents m1 TH_term3">triphenylphosphine catalyzed process for the synthesis of azlactones and their derivatives using hippuric and substituted aromatic aldehydes. The methodology also found to be effective for the synthesis of azlactones from 5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl carbonyl amino acetic acid and offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions, and reduced environmental consequences.