PRENATAL EXPOSURE TO MATERNAL AND PATERNAL DEPRESSIVE SYMPTOMS AND BRAIN MORPHOLOGY: A POPULATION-BASED PROSPECTIVE NEUROIMAGING STUDY IN YOUNG CHILDREN

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• 作者：Hanan El Marroun ; Henning Tiemeier ; Ryan L. Muetzel ; Sandra Thijssen ; Noortje J. F. van der Knaap ; Vincent W. V. Jaddoe ; Guillé ; n Ferná ; ndez ; Frank C. Verhulst and Tonya J. H. White
• 刊名：Depression and Anxiety
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：33
• 期：7
• 页码：658-666
• 全文大小：359K
• ISSN：1520-6394

文摘

Prenatal depressive symptoms have been associated with multiple adverse outcomes. Previously, we demonstrated that prenatal depressive symptoms were associated with impaired growth of the fetus and increased behavioral problems in children aged between 1.5 and 6 years. In this prospective study, we aimed to assess whether prenatal maternal depressive symptoms at 3 years have long-term consequences on brain development in a cohort of children aged 6–10 years. As a contrast, the association of paternal depressive symptoms during pregnancy and brain morphology was assessed to serve as a marker of background confounding due to shared genetic and environmental family factors.