Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

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• 作者：Dario L. Longo ; Rachele Stefania ; Chiara Callari ; Francesco De Rose ; Riccardo Rolle ; Laura Conti ; Lorena Consolino ; Francesca Arena and Silvio Aime
• 刊名：Advanced Healthcare Materials
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：6
• 期：1
• 全文大小：867K
• ISSN：2192-2659

文摘

A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.