Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones

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• 作者：Jianfei Yu ; Meng Duan ; Weilong Wu ; Xiaotian Qi ; Peng Xue ; Prof. Yu Lan ; Prof. Xiu-Qin Dong and Prof. Xumu Zhang
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：23
• 期：4
• 页码：970-975
• 全文大小：1750K
• ISSN：1521-3765

文摘

We have successfully developed a series of novel and modular ferrorence-based amino-phosphine-alcohol (f-Amphol) ligands, and applied them to iridium-catalyzed asymmetric hydrogenation of various simple ketones to afford the corresponding chiral alcohols with excellent enantioselectivities and conversions (98–99.9 % ee, >99 % conversion, turnover number up to 200 000). Control experiments and density functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asymmetric hydrogenation.