Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells

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• 作者：Ke Xiong ; Wei Wei ; Yongjie Jin ; Shumin Wang ; Dongxu Zhao ; Shuang Wang ; Xiaoyong Gao ; Chenmeng Qiao ; Hua Yue ; Guanghui Ma and Hai-Yan Xie
• 刊名：Advanced Materials
• 出版年：2016
• 出版时间：September 28, 2016
• 年：2016
• 卷：28
• 期：36
• 页码：7929-7935
• 全文大小：1923K
• ISSN：1521-4095

文摘

A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.