Practical Synthesis of Chromeno[2,3-b]indole Skeleton via an Aldehyde Group Insertion/Aromatization Strategy

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• 作者：Dr. Jianming Liu ; Na Liu ; Dr. Yuanyuan Yue ; Yanyan Wang ; Kaige Chen ; Jia Zhang ; Shufang Zhao and Dr. Kelei Zhuo
• 刊名：Chemistry – An Asian Journal
• 出版年：2017
• 出版时间：February 16, 2017
• 年：2017
• 卷：12
• 期：4
• 页码：401-404
• 全文大小：1093K
• ISSN：1861-471X

文摘

The synthesis of chromeno[2,3-b]indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack from salicylaldehyde, followed by intramolecular insertion of an aldehyde group and aromatization to generate the desired chromeno[2,3-b]indoles. Moreover, various functional groups were tolerated and a gram-scale synthesis of the product could be achieved under the optimized condition.