A DRD4 gene by maternal sensitivity interaction predicts risk for overweight or obesity in two independent cohorts of preschool children

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• 作者：Robert D. Levitan ; Pauline Jansen ; Barbara Wendland ; Henning Tiemeier ; Vincent W. Jaddoe ; Patricia P. Silveira ; James L. Kennedy ; Leslie Atkinson ; Alison Fleming ; Marla Sokolowski ; Helene Gaudreau ; Meir Steiner ; Laurette Dubé ; Jill Hamilton ; Ellen Moss ; Ashley Wazana and Michael Meaney
• 刊名：Journal of Child Psychology and Psychiatry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：2
• 页码：180-188
• 全文大小：116K
• ISSN：1469-7610

文摘

Recent evidence suggests that early exposure to low maternal sensitivity is a risk factor for obesity in children and adolescents. A separate line of study shows that the seven-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) increases susceptibility to environmental factors including maternal sensitivity. The current study integrates these lines of work by examining whether preschoolers carrying the 7R allele are more vulnerable to low maternal sensitivity as it relates to overweight/obesity risk.