Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

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• 作者：Kentaro Nakashima ; Yuichi Kodama ; Takuro Nishikawa ; Miho Nishimura ; Nobuhiro Ito ; Reiji Fukano ; Yuko Nomura ; Tetsuya Ueba ; Tooru Inoue ; Koichi Oshima ; Jun Okamura and Jiro Inagaki
• 刊名：Pediatrics International
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：58
• 期：5
• 页码：388-390
• 全文大小：370K
• ISSN：1442-200X

文摘

Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.