Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53

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Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53

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作者：Jing wang^b ; ^c ; ¹ ; Yue Zhang^b ; ¹ ; Qiuzhen Zhu^a ; Yulan Liu^a ; Hao Cheng^b ; Yuefan Zhang^a ; ^{zhangyuefan@126.com" class="auth_mail" title="E-mail the corresponding author} ; Tiejun Li^a ; ^b ; ^c ; ^{ltj204@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Gamma radiation ; Emodin ; Intestinal injury ; Apoptosis ; p53
刊名：Environmental Toxicology and Pharmacology
出版年：2016
出版时间：September 2016
年：2016
卷：46
期：Complete
页码：311-318
全文大小：3720 K

文摘

•: Emodin, an anthraquinone, protects gamma radiation-induced mortality in mice.
•: Emodin protects mice against gamma radiation-induced intestinal injury.
•: Emodin increases viability and inhibits apoptosis in HUVECs after radiation.
•: Emodin suppresses the apoptotic signaling pathway in HUVECs after irradiation.

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