Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

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• 作者：Mohammed K. Hankirp>1p>p> ; p>p>10p> ; Florian Seyfriedp>2p>p> ; p>p>10p> ; Constantin A. Hintschichp>1p>p> ; p>p>10p> ; Thi-Ai Diepp>3p> ; Karen Klebergp>4p> ; Mathias Kranzp>5p> ; Winnie Deuther-Conradp>5p> ; Luis A. Tellezp>8p> ; Michael Rullmannp>6p> ; Marianne Pattp>6p> ; Jens Teichertp>7p> ; Swen Hessep>1p>p> ; p>p>6p> ; Osama Sabrip>1p>p> ; p>p>6p> ; Peter Brustp>5p> ; Harald S. Hansenp>4p> ; Ivan E. de Araujop>8p> ; Ute Kr&uuml ; gelp>9p>p> ; p>p>ute.kruegel@medizin.uni-leipzig.dep> ; Wiebke K. Fenskep>1p>p> ; p>p>11p>p> ; p>p>wiebkekristin.fenske@medizin.uni-leipzig.dep>
• 关键词：gastric bypass surgery ; fat appetite ; altered nutrient preference ; dopamine system ; D1R signaling ; OEA ; PPAR-alpha ; [11C] SCH 23390
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：335-344
• 全文大小：2366 K
• 卷排序：25

文摘

RYGB increases meal-stimulated intestinal OEA synthesis and striatal DA release Enhanced striatal DA responses caused by RYGB require an intact vagus nerve RYGB upregulates striatal D1Rs specifically under HF feeding conditions RYGB effects on fat appetite require intact gut PPARα and striatal D1R signaling