Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance

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Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance

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作者：Eiichiro Mori^a ; ^b ; Anthony J. Davis^a ; Masatoshi Hasegawa^b ; David J. Chen^a ; ^{David.Chen@UTSouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：DNA double-strand breaks ; Non-homologous end-joining ; Acetylation ; DNA-PKcs
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：19 August 2016
年：2016
卷：477
期：2
页码：235-240
全文大小：841 K

文摘

•: DNA-PKcs is acetylated in cells.
•: Mutating K3241 and K3260 of DNA-PKcs results in increased radiosensitivity.
•: Mutating K3241 and K3260 of DNA-PKcs results in genomic instability.

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