A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses

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A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses

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作者：Ji-Rong Yang^a ; ^b ; ^c ; Chih-Yuan Chen^b ; Chuan-Yi Kuo^b ; Chieh-Yu Cheng^b ; Min-Shiuh Lee^d ; Ming-Chu Cheng^d ; Yu-Chih Yang^c ; Chia-Ying Wu^c ; Ho-Sheng Wu^b ; ^e ; Ming-Tsan Liu^b ; ^{mtliu@cdc.gov.tw" class="auth_mail" title="E-mail the corresponding author} ; Pei-Wen Hsiao^a ; ^c ; ^{pwhsiao@gate.sinica.edu.tw" class="auth_mail" title="E-mail the corresponding author}
关键词：Influenza A (H6N1) virus ; Virus-like particle vaccine ; Broad-spectrum protective immunity
刊名：Antiviral Research
出版年：2016
出版时间：February 2016
年：2016
卷：126
期：Complete
页码：8-17
全文大小：2300 K

文摘

•: This study characterizes the first H6N1 vaccine against human and avian influenza viruses.
•: H6N1-VLP vaccine induced antibodies that neutralized viruses in vivo and in vitro.
•: H6N1-VLP antibodies neutralized conserved epitopes in the HA head and stem domains.
•: VLP antibodies neutralized hemagglutination and replication in cross-clade viruses.

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