Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases
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文摘
Apolipoproteins such as apoA-I, apoA-II and SAA can cause systemic amyloidoses. Binding to high-density lipoproteins protects these proteins from misfolding. Free apolipoproteins are intrinsically disordered and labile to misfolding. Increasing triglyceride levels in human or model HDL promotes protein release. Triglyceride-lowering therapies may potentially alleviate apolipoprotein amyloidoses.
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