Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion

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• 作者：Erin Kate McNally¹ ; Mahmoud Abdul Karim¹ ; Christopher Leonard Brett¹ ; ² ; ^{christopher.brett@concordia.ca}
• 关键词：protein degradation ; protein quality control ; membrane fusion ; intralumenal fragment ; TOR ; multivesicular body ; lysosome biology ; vacuole ; lysosomal transporter
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：40
• 期：2
• 页码：151-167
• 全文大小：8146 K
• 卷排序：40

文摘

Lysosomal polytopic proteins are sorted and degraded upon organelle membrane fusion This ESCRT-independent process requires the fusion machinery for protein sorting This process mediates protein quality control and responds to substrate levels and TOR Called the ILF pathway, this process underlies lysosome homeostasis and remodeling