Investigations on the role of ¦Ð-¦Ð interactions and ¦Ð-¦Ð networks in eNOS and nNOS proteins

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• 作者：Sivasakthi Vaideeswaran ; Sudha Ramaiah
• 关键词：eNOS ; endothelial Nitric Oxide Synthase ; nNOS ; neuronal Nitric Oxide Synthase ; ASA ; Accessible surface area ; NCI ; Non-canonical interactions ; PDB ; Protein Data Bank ; SC ; stabilization center
• 刊名：Bioorganic Chemistry
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：49
• 期：Complete
• 页码：16-23
• 全文大小：2203 K

文摘

¦Ð-¦Ð Interactions play an important role in the stability of protein structures. In the present study, we have analyzed the influence of ¦Ð-¦Ð interactions in eNOS and nNOS proteins. The contribution of these ¦Ð-¦Ð interacting residues in sequential separation, secondary structure involvement, solvent accessibility and stabilization centers has been evaluated. ¦Ð-¦Ð interactions stabilize the core regions within eNOS and nNOS proteins. ¦Ð-¦Ð interacting residues are evolutionary conserved. There is a significant number of ¦Ð-¦Ð interactions in spite of the lesser natural occurrences of ¦Ð-residues in eNOS and nNOS proteins. In addition to ¦Ð-¦Ð interactions, ¦Ð residues also form ¦Ð-¦Ð networks in both eNOS and nNOS proteins which might play an important role in the structural stability of these protein structures.