Physicochemical characterization and in vivo evaluation of triamcinolone acetonide-loaded hydroxyapatite nanocomposites for treatment of rheumatoid arthritis

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Physicochemical characterization and in vivo evaluation of triamcinolone acetonide-loaded hydroxyapatite nanocomposites for treatment of rheumatoid arthritis

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作者：Samira Jafari^a ; ^b ; Nasrin Maleki-Dizaji^c ; Jaleh Barar^a ; Mohammad Barzegar-Jalali^d ; Maryam Rameshrad^b ; ^c ; Khosro Adibkia^d ; ^{adibkia@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author}
关键词：Triamcinolone acetonide ; Hydroxyapatite ; Nanocomposite ; Cytotoxicity ; Rheumatoid arthritis ; Haematological assessment
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2016
出版时间：1 April 2016
年：2016
卷：140
期：Complete
页码：223-232
全文大小：2910 K

文摘

•: HAp nanocomposites were synthesized through a chemical precipitation method.
•: The physicochemical properties of the synthesized nanocomposites were examined.
•: Structural features of the nanocomposites were estimated using BET and BJH.
•: The prepared nanoformulation had lower cytotoxicity compared to the pure drug.
•: The nanocomposites showed significant anti-inflammatory effects in the rats.