Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats

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Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats

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作者：Agnieszka Nikiforuk ; ^{nikifor@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author} ; Tomasz Kos ; Małgorzata Hołuj ; Agnieszka Potasiewicz ; Piotr Popik
关键词：Alpha 7 nicotinic acetylcholine receptors ; Positive allosteric modulators ; Schizophrenia ; Animal models ; Cognition ; Ketamine
刊名：Neuropharmacology
出版年：2016
出版时间：February 2016
年：2016
卷：101
期：Complete
页码：389-400
全文大小：1625 K

文摘

•: We evaluated the efficacies of α7-nAChRs PAMs in an animal model of schizophrenia.
•: PNU-120596 and CCMI reversed ketamine-induced cognitive impairments.
•: Both α7-nAChRs PAMs ameliorated ketamine-induced social interaction deficits.
•: The efficacies of α7-nAChRs PAMs were comparable to those of A-582941.
•: Galantamine also demonstrated procognitive, but not prosocial, efficacy.

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