Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration

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Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration

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作者：O.D. Konsta^a ; ^b ; C. Le Dantec^a ; A. Charras^a ; D. Cornec^a ; E.K. Kapsogeorgou^b ; A.G. Tzioufas^b ; J.O. Pers^a ; Y. Renaudineau^a ; ^c ; ^{yves.renaudineau@univ-brest.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Sjö ; gren's syndrome ; DNA demethylation ; Anti-SSB antibodies ; Lymphocytes
刊名：Journal of Autoimmunity
出版年：2016
出版时间：April 2016
年：2016
卷：68
期：Complete
页码：30-38
全文大小：1698 K

文摘

•: Defective global DNA methylation is observed in epithelial cells from pSS patients.
•: Lymphocyte infiltration might influence DNA methylation in epithelial acini.
•: DNA methylation controls SSB gene expression.
•: DNA demethylation might influence the emergence of SSB/La antibody production.

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