Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

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• 作者：Niamh Conlon ; MB ; FRCPath ; ^{conlon_niamh@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Navid Sadri ; MD ; PhD ; Adriana D. Corben ; MD ; Lee K. Tan ; MD
• 关键词：Acinic cell carcinoma of breast ; Triple-negative breast cancer ; Morphology ; Immunohistochemistry ; Molecular pathology
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：51
• 期：Complete
• 页码：16-24
• 全文大小：2492 K

文摘

Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis–like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.