Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers

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Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers

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作者：Loren J. Martin^&lowast ; ; ^&dagger ; ; ^&Dagger ; ; ^{lj.martin@utoronto.ca" class="auth_mail" title="E-mail the corresponding author} ; Marjo H. Piltonen^&dagger ; ; ^§ ; ; Josee Gauthier^¶ ; ; Marino Convertino^‖ ; Erinn L. Acland^&lowast ; ; ^&dagger ; ; ^&Dagger ; ; Nikolay V. Dokholyan^‖ ; Jeffrey S. Mogil^&lowast ; ; ^&dagger ; ; Luda Diatchenko^&dagger ; ; ^§ ; ; ^¶ ; ; William Maixner^¶ ;
关键词：Pain ; propranolol ; bupranolol ; β-adrenergic receptors ; antinociception
刊名：The Journal of Pain
出版年：2015
出版时间：December 2015
年：2015
卷：16
期：12
页码：1321-1333
全文大小：1359 K

文摘

•: Enantiomers of propranolol and bupranolol were compared for antinociception.
•: S-Bupranolol is a superior antinoceptive agent on mouse models of persistent pain.
•: S-Bupranolol exhibited fewer side effects than propranolol or associated enantiomers.
•: S-Bupranolol produced a unique blockade of β₃-adrenergic receptors.

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