Contextual signaling in cancer

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Contextual signaling in cancer

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作者：Laura J. Smithson ; Corina Anastasaki ; Ran Chen ; Joseph A. Toonen ; Sidney B. Williams ; David H. Gutmann ; ^{gutmannd@wustl.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：AKT ; protein kinase B ; ATF4 ; activating transcription factor 4 ; cAMP ; cyclic adenosine monophosphate ; CCL5 ; (C-C motif) ligand 5 ; CNS ; central nervous system ; 4EBP1 ; 4E (elF4E) binding protein ; ECM ; extracellular matrix ; ERK ; p44/p42 extracellular signal-related kinase ; GAP ; GTPase-activating protein ; GRK2 ; G protein-coupled receptor kinase 2 ; HGG ; high grade glioma ; HVR ; hypervariable region ; iPSCs ; induced pluripotent stem cells ; JNK ; c-Jun N-terminal kinases ; MEK ; mitogen-activated protein ki
刊名：Seminars in Cell & Developmental Biology
出版年：2016
出版时间：October 2016
年：2016
卷：58
期：Complete
页码：118-126
全文大小：2578 K

文摘

•: Cellular responses are dictated by context-dependent signaling pathway engagement.
•: 10">A limited number of molecules can activate multiple downstream effectors.
•: 15">Specific effector pathways are activated in a cell type and tissue-specific manner.
•: Extracellular cues and genomic/genetic factors modify signaling pathway output.

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