Ikaros and its interacting partner CtBP target the metalloprotease ADAMTS10 to modulate pituitary cell function

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• 作者：Zhongyi Shen^a ; ^c ; Sylvia L. Asa^a ; ^c ; Shereen Ezzat^b ; ^c ; ^{shereen.ezzat@utoronto.ca}
• 关键词：Ikaros ; CtBP ; ADAMTS10 ; Pituitary tumors ; Hypoxia
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：126-132
• 全文大小：1290 K
• 卷排序：439

文摘

Ikaros & C-terminal Binding Protein (CtBP) coordinate pituitary response to hypoxia. The metalloprotease ADAMTS10 is a target of Ikaros and CtBP in pituitary cells. ADAMTS10 is expressed in anterior pituitary cells & diminished in Ikaros-null mice. ADAMTS10 modulates proliferation and ACTH secretion in AtT20 pituitary cells. ADAMTS10 is a candidate modulator of pituitary growth factor responses to hypoxia.