The extracellular matrix in cancer progression: Role of hyalectan proteoglycans and ADAMTS enzymes

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• 作者：Marley J. Binder^a ; Scott McCoombe^a ; Elizabeth D. Williams^c ; Daniel R. McCulloch^a ; ^b ; ¹ ; Alister C. Ward^a ; ^b ; ¹ ; ^{alister.ward@deakin.edu.au}
• 关键词：Extracellular matrix ; Cancer ; Hyalectan ; Versican ; ADAMTS
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：55-64
• 全文大小：1491 K
• 卷排序：385

文摘

Extracellular matrix (ECM) remodelling is an emerging area of cancer biology. Proteoglycans such as versican are key ECM components implicated in cancer progression. ADAMTS metalloproteinases cleave proteoglycans and typically act as tumour suppressors. Additional layers of complexity due to alternate isoforms, non-enzymatic functions and cell context.