Components of the lectin pathway of complement activation in paediatric patients of intensive care units

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Components of the lectin pathway of complement activation in paediatric patients of intensive care units

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作者：Anna S. Świerzko^a ; Agnieszka Szala-Poździej^a ; David C. Kilpatrick^b ; Michał Sobociński^c ; Karolina Chojnacka^d ; Anna Sokołowska^a ; Mateusz Michalski^a ; ^e ; Karolina Mazerant^a ; Jens C. Jensenius^f ; Misao Matsushita^g ; Wojciech R. Krajewski^c ; Jerzy Szczapa^d ; Leokadia Bąk-Romaniszyn^h ; Krzysztof Zemanⁱ ; Maciej Cedzyński^a ; ^{mcedzynski@cbm.pan.pl" class="auth_mail" title="E-mail the corresponding author} ; ^{mcedzyns@poczta.onet.pl" class="auth_mail" title="E-mail the corresponding author}
关键词：MASP ; mannose-binding lectin-associated serine protease ; MBL ; mannose-binding lectin ; SIRS ; systemic inflammatory response syndrome
刊名：Immunobiology
出版年：2016
出版时间：May 2016
年：2016
卷：221
期：5
页码：657-669
全文大小：1773 K

文摘

•: Low MBL-conferring genotypes (LXA/O + O/O) were associated with paediatric sepsis.
•: Low serum MBL, ficolin-2 and -3 on admission were associated with paediatric sepsis.
•: Low ficolin-3 seemed to be associated with higher mortality from neonatal sepsis.
•: No impact of SNPs of FCN1, FCN2, FCN3, MASP1/3, MASP2, TLR2, TLR4 genes was found.

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