Identification and characterization of in vitro and in vivo generated metabolites of the adiponectin receptor agonists AdipoRon and 112254

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Identification and characterization of in vitro and in vivo generated metabolites of the adiponectin receptor agonists AdipoRon and 112254

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作者：Josef Dib^a ; Andreas Thomas^a ; Philippe Delahaut^b ; Eric Fichant^b ; Wilhelm Schä ; nzer^a ; Mario Thevis^a ; ^c ; ^{thevis@dshs-koeln.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Sport ; Doping ; Mass spectrometry ; Exercise mimetic ; Metabolism
刊名：Journal of Pharmaceutical and Biomedical Analysis
出版年：2016
出版时间：5 June 2016
年：2016
卷：125
期：Complete
页码：68-76
全文大小：1837 K

文摘

•: In vitro- and in vivo-metabolism study of adipoR agonists AdipoRon and 112254.
•: Identification of metabolites relevant for routine doping control assays.
•: Characterization via high resolution/high accuracy—tandem mass spectrometry.
•: Overlapping patterns of phase-I metabolites were observed in vitro and in vivo.
•: AdipoRon yielded phase-II metabolites in vivo (rat).

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