Induction of tolerance and prolongation of islet allograft survival by syngeneic hematopoietic stem cell transplantation in mice

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Induction of tolerance and prolongation of islet allograft survival by syngeneic hematopoietic stem cell transplantation in mice

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作者：Shi-feng Yang^a ; ^{37025626@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Wu-jun Xue^b ; ^{jeffysy@live.cn" class="auth_mail" title="E-mail the corresponding author} ; Wan-hong Lu^a ; ^{Lu_wanhong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Li-yi Xie^a ; ^{xieliyi0313@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ai-ping Yin^a ; ^{aipingy@126.com" class="auth_mail" title="E-mail the corresponding author} ; Jin Zheng^b ; ^{jzheng@xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ji-ping Sun^a ; ^{sunjiping_angel@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Yang Li^b ; ^{jullian80915@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：GVHD ; graft-versus-host disease ; GFP ; green fluorescent protein ; HSCs ; hematopoietic stem cells ; HSCT ; hematopoietic stem cell transplantation ; IFN-纬 ; interferon-纬 ; IL-2 ; interleukin-2 ; IL-4 ; interleukin-4 ; MST ; median survival time ; MLR ; mixed lymphocyte reaction ; PBMCs ; peripheral blood mononuclear cells ; PBS ; phosphate buffered saline ; STZ ; streptozotocin
刊名：Transplant Immunology
出版年：2015
出版时间：October 2015
年：2015
卷：33
期：2
页码：130-139
全文大小：1628 K

文摘

•: Syngeneic HSCT induces tolerance and improves islet allograft survival.
•: Syngeneic HSCT results in anergy of alloimmune reactive T cells.
•: Syngeneic HSCT up-regulates CTLA-4 expression of T cells.
•: Syngeneic HSCT promotes Th1 to Th2 immune deviation.
•: Syngeneic HSCT leads to increased T regulatory cells.

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