S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle

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• 作者：Yu-Dong Xu^a ; Yu Wang^a ; Lei-Miao Yin^a ; Gyoung-Hee Park^a ; Luis Ulloa^a ; ^b ; ^{Luis.Ulloa@Rutgers.edu} ; Yong-Qing Yang^a ; ^{yyq@shutcm.edu.cn}
• 关键词：S100A8 ; Asthma ; Airway hyperresponsiveness ; Airway smooth muscle ; Contraction
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：184-188
• 全文大小：651 K
• 卷排序：484

文摘

S100A8 protein attenuates airway hyperresponsiveness in asthmatic rats. S100A8 reduced hypercontractility of tracheal rings and ASM cells treated with Ach. S100A8 may be an effective therapeutic candidate for ASM contraction.