Racemic alkaloids from the fungus Ganoderma cochlear

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• 关键词：Ganoderma cochlear ; Alkaloids ; ECD calculations ; Racemates ; Biosynthesis
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：93-98
• 全文大小：445 K
• 卷排序：116

文摘

Seven pairs of new alkaloid enantiomers, ganocochlearines C − I (1, 3–8), and three pairs of known alkaloids were isolated from the fruiting bodies of Ganoderma cochlear. The chemical structures of new compounds were elucidated on the basis of 1D and 2D NMR data. The absolute configurations of compounds 1, 3–10 were assigned by ECD calculations. Biological activities of these isolates against renal fibrosis were accessed in rat normal or diseased renal interstitial fibroblast cells. Importantly, the plausible biosynthetic pathway for this class of alkaloids was originally proposed.