Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors

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• 作者：Guanqun Zhan^a ; Junjun Liu^a ; Junfei Zhou^a ; Bin Sun^a ; Haji Akber Aisa^b ; Guangmin Yao^a ; ^{gyap@mail.hust.edu.cn}
• 关键词：Alzheimer's disease ; AChE inhibitory activity ; Docking studies ; Zephyranthes candida ; Amaryllidaceae alkaloids
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：771-780
• 全文大小：1629 K
• 卷排序：127

文摘

Three new Amaryllidaceae alkaloids 1–3 were isolated from Zephyranthes candida. Compound 1 is the first example of 7-phenyl-hexahydroindole alkaloids. Compound 3 is the first example of 5,2'-dimethyl-biphenyl-2-ylamine alkaloids. New Amaryllidaceae alkaloid 3 has a potent AChE inhibitory activity. Docking studies revealed that interactions with W286 and Y337 are necessary.