Differential response to anodal tDCS and PAS is indicative of impaired focal LTP-like plasticity in schizophrenia

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Differential response to anodal tDCS and PAS is indicative of impaired focal LTP-like plasticity in schizophrenia

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作者：Wolfgang Strube^a ; ^{wolfgang.strube@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Tilmann Bunse^a ; ^{tilmann.bunse@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Michael A. Nitsche^b ; ^c ; ^{mnitsch1@gwdg.de" class="auth_mail" title="E-mail the corresponding author} ; Ulrich Palm^a ; ^{ulrich.palm@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Peter Falkai^a ; ^{peter.falkai@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Alkomiet Hasan^a ; ^{alkomiet.hasan@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Schizophrenia ; Paired associative stimulation (PAS) ; Anodal transcranial direct current stimulation (tDCS) ; Long term potentiation (LTP) ; Like plasticity ; Focality ; Transcranial magnetic stimulation (TMS)
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 September 2016
年：2016
卷：311
期：Complete
页码：46-53
全文大小：1028 K

文摘

•: Non-focal and focal plasticity mechanisms were comparatively evaluated.
•: Anodal tDCS induced non-focal LTP-like plasticity both in schizophrenia and controls.
•: Following PAS, reduced focal LTP-like plasticity was observed in schizophrenia.
•: This differential pattern indicates impaired temporal-spatial signal integration.

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