High throughput HPLC-ESI<sup>−</sup>-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation

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High throughput HPLC-ESI⁻-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation

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作者：Srikanth Kotapati^a ; ^b ; Amanda Esades^b ; ^c ; Brock Matter^b ; Chap Le^d ; Natalia Tretyakova^a ; ^b ; ^{trety001@umn.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BD ; 1 ; 3-butadiene ; EB ; 3 ; 4-epoxy-1-butene ; HMVK ; hydroxymethyl vinyl ketone ; EBD ; 3 ; 4-epoxy-1 ; 2-diol ; DEB ; 1 ; 2 ; 3 ; 4-diepoxybutane ; MHBMA ; monohydroxybutenyl mercapturic acid ; DHBMA ; dihydroxybutyl mercapturic acid ; THBMA ; trihydroxybutyl mercapturic acid ; THB-Val ; 1 ; 2 ; 3-trihydroxybutyl-valine ; Pyr-Val ; N ; N-(2 ; 3-dihydroxy-1 ; 4-butadiyl)-valine ; EH ; epoxide hydrolase ; GST ; glutathione S-transferase ; HPLC-ESI&minus ; -MS/MS ; high performance liquid chromatography-electrospray ionization tandem mass spe
刊名：Chemico-Biological Interactions
出版年：2015
出版时间：5 November 2015
年：2015
卷：241
期：Complete
页码：23-31
全文大小：607 K

文摘

•: New HPLC–ESI⁻-MS/MS method was developed for urinary metabolites of 1,3-butadiene.
•: BD-mercapturic acids were quantified in occupationally exposed workers and controls.
•: BD-mercapturic acid levels were increased in BD exposed workers.
•: Urinary BD-mercapturic acids were associated with BD-hemoglobin adducts in blood.

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