Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase

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Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase

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作者：Raghunath Aeluri^a ; ¹ ; Roopa Jones Ganji^b ; ¹ ; Anil Kumar Marapaka^b ; Vijaykumar Pillalamarri^b ; Manjula Alla^a ; ^{manjula@iict.res.in" class="auth_mail" title="E-mail the corresponding author} ; Anthony Addlagatta^b ; ^{anthony@iict.res.in" class="auth_mail" title="E-mail the corresponding author}
关键词：Tetrahydropyridine ; Multicomponent reaction ; Cytotoxicity ; Puromycin sensitive aminopeptidase and inhibitors
刊名：European Journal of Medicinal Chemistry
出版年：2015
出版时间：1 December 2015
年：2015
卷：106
期：Complete
页码：26-33
全文大小：740 K

文摘

•: Multiple synthetic routes designed for construction of THPs and related piperidines.
•: 2,6-Differently substituted THPs have been achieved via modified one pot MCR.
•: Cytotoxicity and Enzyme inhibition against M1 family of aminopeptidases.
•: THPs selectively inhibit hPSA among M1 family of aminopeptidases.
•: Four compounds exhibited hPSA enzyme inhibition equal to or better than puromycin.

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